journal description

The Journal of Medical Research and Innovation (JMRI) is an award-winning and open peer-reviewed journal which covers all aspects of Medicine including cellular biology, zoology and futuristic medicine (Robotics and Artificial Intelligence in medicine). The journal will feature original research, reviews, editorials, case studies, brief communications, opinions/views, poster presentations and audios & videos. This will be of interest to medical practitioners, clinical educators, nurse practitioners and other healthcare professionals involved in the care of patients.

The journal publishes at least two issues (Bi-Annually. First issue in January and Second in July) each year. Articles are published online when ready for publication (Continuously) as Article in Press. Additional issues may be published for special events (e.g. conferences) and when special themes are addressed. 

ISSN: 2456-8139, Editor in Chief: Dr. Varshil Mehta, Publisher: Medkrux
Open-Access: Delayed (12 months) for subscription based while Immediate for Open-Access Articles
Frequency: Bi-Annually (Semi-Continuous Model), APC: NIL, Contact us:

Original Article

Unequal Effects of Educational Attainment on Workplace Exposure to Second-Hand Smoke by Race and Ethnicity; Minorities’ Diminished Returns in the National Health Interview Survey (NHIS)

by Assari S., Bazargan M.

Summary: One of the mechanisms by which high educational attainment promotes populations’ health is through reducing exposure to environmental risk factors such as second-hand smoke. Minorities’ Diminished Returns theory, however, posits that the protective effect of educational attainment may be smaller for racial and ethnic minority individuals particularly Blacks and Hispanics compared to Whites.

Review Article

Transcatheter aortic valve replacement in Bicuspid Aortic Valve Disease: An Insight

by Mehta V., Nalluri N., Kumar V., Patel N., Atti V., Narula A., Cohen M.

Summary: As per the current scenario, role of Transcatheter aortic valve replacement (TAVI) is controversial in bicuspid aortic valve stenosis. All the randomized clinical trials comparing outcomes of TAVI with surgery till date, have excluded patients with bicuspid aortic valve. Some of the observational studies have reported outcomes of TAVI in bicuspid aortic valve stenosis patients who are not surgical candidate. The recent advances in TAVI and its expansion into intermediate groups, which includes younger age groups sparks a debate on the efficacy and safety of TAVI in Bicsuspid aortic valve (BAV). The purpose of the present article is to review the available literature regarding the feasibility, safety and outcomes of TAVI in bicuspid aortic valve stenosis.

Original Article

Psychosocial determinants of communication satisfaction in racially concordant and discordant patient-physician interactions

by Assari S.

Summary: Although both socioeconomic and race- related factors both influence quality of medical encounters, it is not known how these effects differ between racially concordant and discordant medical visits. Current study investigated psychosocial determinants of physician visit satisfaction of Black adults based on racial concordance of the medical encounter.

Original Article

Metformin Inhibits Growth of Breast Cancer Cell T47D through Decreasing Expression of Protein P53, BCL2 and Cyclin D1

by Rangkuti I., Hasibuan P., Widyawati T., Siregar Y.

Summary: Breast cancer is a disease that afflicts women only 0.5 to 1 % are male breast cancers.Breast cancer has several variants and requires a different therapeutic approach, and until now the therapy has not been satisfactory due to the emergence of resistance. Metformin as the main choice drug type 2 diabetes mellitus which is known to have a cytotoxic effect for breast cancer. This study aimed to analyze metformin cytotoxic mechanisms covering the cell cycle , apoptosis, expression of p53, bcl-2 and cyclin D1 T47D cells which exposed to metformin HCl. The study was conducted invitro on T47D breast cancer cells which exposed to metformin concentrations of 1738.2 µg / mL and 3476.4 µg / mL and doxorubicin concentrations of 0.1µg / mL and 0.2µg / mL for 24 hours. Cell cycle testing and apoptosis using the flowsitometry method and expression test of p53 protein, bcl-2 dancycline D1 in T47D cells with immunocytochemistry. Data was analyzed by one way Anova with Bonferroni's advanced test. The results showed that metformin inhibited the G0-G1 phase of the T47D cell cycle, triggered T47D cell apoptosis, significantly reduced p53, bcl-2 and cyclin D1 protein expression (p <0.05). Conclusion of the study, metformin inhibits T47D cells through inhibition of the cell cycle G0-G1 phase, reducing protein expression p53, bcl-2 and cyclin D1.


Non-Spinal Causes of Back Pain: An ‘undiagnosed’ diagnosis

by Goel S.

Summary: Low back pain is a common ailment affecting individuals all around the globe. Majority of Disability Adjusted Life Years lost amongst working population is due to low back pain. Though majority of surgeons/physicians keep only spinal causes in mind while treating such an ailments, a number of other causes exist for such a pathology. This editorial aims to make the readers aware about such non spinal causes of low back pain.

Subscription/Printing services

The subscription/printing for/of the Journal of Medical Research and Innovation shall be managed/handled by AkiNik Publications, New Delhi, India. The subscription charges will be ₹3000 or $120 per year.  

All subscriptions are payable in advance and all rates include postage and taxes. Issues will be sent on receipt of
payment. Subscriptions are entered on an annual basis and are subject to renewal in subsequent years.

Please fill this form: and send this form with payment to (By speed post/courier only):
Subscription Manager, AkiNik Publications
H. No. 169, Pocket C-11, Sector-3, Rohini, New Delhi-110085, India.
Ph.:+91-9711224068; E-mail:; web.:

Average peer reviewing time of JMRI

The current average peer reviewing time is appx. 7 weeks. However, the average time for the first decision made is appx. 5 weeks.

There is a possibility that the time for your paper may vary, if we do not find relevant reviewers for your paper. However, you can help us with this regard by providing the names of two reviewers who can potentially review your paper (Cannot be from your institution or who have worked with you in last one year).

Please bear with us, as we try our best to find reviewers in time. But, we promise to provide a fair and timely experience to every one of you.

JMRI shall now display and use CrossMark


We are pleased to say that JMRI shall now display CrossMark on each article published henceforth (may be even all those are already published so far).  This will enable us to provide current information of each published paper. Read more about crossmark at

No publication fees for the articles submitted in 2019

There shall be no charges for the entire 2019 year. Submit your paper soon. Lets make JMRI even better. Cheers to Researchers, Cheers to JMRI !!! 

Medkrux Research Group

After getting many request to start a research group, we have finally started one for all medicos. To read more kindly visit:

Technical Error has now been resolved

Since last few days, we had a technical error and due to which both the sites ( and were not working. However, that glitch has been resolved now. We apologise for the inconvenience that caused to our readers.

New domain (website)

Dear all, 

We have changed our domain from to from today onwards. However, the old domain will be still working and re-direct every one on to the new site automatically.  Kindly note the changes.

Editorial team, JMRI

More Updates